Rambaldi, A.; Jacobs, B.; Iaquinto G, Gluud C. Milk thistle for alcoholic and/or hepatitis B or C liver diseases--a systematic Cochrane hepato-biliary group review with meta-analyses of randomized clinical trials. Milk thistle comes in many forms, including tea. It is unknown if this product passes into breast milk. 2019;33(6):1627-1638. doi:10.1002/ptr.6361. Milk thistle is available as a supplement from many health food stores. What Are the Side Effects of Milk Thistle? Thank you, {{form.email}}, for signing up. However, seek immediate medical attention if you notice any of the following symptoms of a serious allergic reaction: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing. 2005 - 2023 WebMD LLC. There are 4 drugs known to interact with Usually avoid combinations; use it only under special circumstances. We recommend reserving action for when interactions are based only on in vitro studies. US residents can call their local poison control center at 1-800-222-1222. Milk thistle is native to Europe and was introduced into North America by early colonists. Phytother Res. Milk thistle is a plant named for the white veins on its large prickly leaves. Milk thistle may not be safe for everyone. High cholesterol can lead to problems with heart health and increase a persons chance of stroke. However, more direct research is warranted in this regard. Otherwise, call a poison control center right away. Milk thistle may interfere with the following medications, because both milk thistle and these medications are broken down by the same liver enzymes: Reviewed By: Steven D. Ehrlich, N.M.D., private practice specializing in complementary and alternative medicine, Phoenix, AZ. The Natural agonist of estrogen receptor silibinin plays an immunosuppressive role representing a potential therapeutic tool in rheumatoid arthritis. In: StatPearls. Learn more about the other negative effects of this herb and what research says about them. Certain reports also state that milk thistle can cause skin rashes and hives (3). Review of Clinical Trials Evaluating Safety and Efficacy of Milk Thistle (Silybum marianum [L.] Gaertn. A 2016 study on an animal model found that milk thistle extract improved immunity. Milk thistle had no effect on any of the drugs. MNT is the registered trade mark of Healthline Media. (2021). Effect of silymarin (milk thistle) on liver disease in patients with chronic hepatitis C unsuccessfully treated with interferon therapy: a randomized controlled trial. Dosage is also typically listed on the nutrition label of supplements. Click here for additional information. Review provided by VeriMed Healthcare Network. Consult your doctor before using this product. It is native to Mediterranean countries. 3 are moderate, and 1 is minor. The active ingredient in milk thistle, silymarin, acts as an antioxidant by reducing free radical production. Therefore, it is not known whether milk thistle or silymarin should be used to treat cirrhosis. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. Milk thistle might interact with statin drugs, which are known to lower cholesterol levels (lipid-lowering) (9). Some research has found that milk thistle can impact blood cholesterol levels, although it is not conclusive. Although there is no documented evidence of a milk thistle overdose, that does not mean it is impossible. This may help ease symptoms from liver . The name "milk thistle" derives from a feature of the leaves, which are prominently banded with splashes of white. Check out the infographic below to learn more about the benefits of milk thistle.SaveIllustration: StyleCraze Design Team. Of the total drug interactions, 3 are moderate, and 1 is minor. Silymarin, an active component of milk thistle, may improve liver function and reduce symptoms of cirrhosis, or scarring of the liver. Properly discard this product when it is expired or no longer needed. If left untreated, anaphylaxis can lead to shock, coma, cardiac or respiratory failure, or even death. 2005;100(11):2583-91. doi:10.1111/j.1572-0241.2005.00262.x. Evidence and risks, Debra Rose Wilson, Ph.D., MSN, R.N., IBCLC, AHN-BC, CHT, protecting the liver, immune system, and kidneys, providing antiviral, antifungal, and antibacterial properties, reducing the risk of diabetes, arthritis, and obesity. Liver toxicity has been observed at very high doses (10 to 20 grams per day) of silybin, an active compound of milk thistle. Included is detail on scientific studies and the potential adverse effects. We know little about whether milk thistle is effective in people, as only a few well-designed clinical studies have been conducted. The terms milk thistle and silymarin are often used interchangeably. If your condition lasts or gets worse, or if you think you may have a serious medical problem, get medical help right away. Milk thistle is now found throughout the eastern United States, California, South America, Africa, Australia, and Asia. We encourage you to discuss any decisions about treatment or care with your health care provider. These side effects may be mild or severe. Toxicity is also possible if too much milk thistle is taken. Historically, people have used milk thistle for liver disorders and gallbladder problems. Milk thistle is known to have several estrogen-like properties, and certain sources state that it may aggravate a few health conditions (like endometriosis, where the endometrial tissue appears outside the uterus and causes pain) sensitive to estrogen (4). Canada residents can call a provincial poison control center. Do not flush medications down the toilet or pour them into a drain unless instructed to do so. NCCIH has provided this material for your information. 1982;17:51721. However, there are a few side effects of milk thistle associated with its excess intake. Calm an upset stomach. The following list is not exhaustive. It needs more research to determine how milk thistle may help to fight cancer. Milk thistle is promoted as a dietary supplement for hepatitis, cirrhosis, jaundice, diabetes, indigestion, and other conditions. Store milk thistle supplements in a cool, dry place. Does Milk Thistle Capsule interact with other medications? Silymarin is an active compound found in milk thistle seeds. Milk thistle (Silybum marianum) contains silymarin which is a mixture of flavonolignans, mainly silibinin (also known as silybin), as well as silycristine, silydianin, quercetin and taxifolin. Researchers also found in another study that milk thistle had antioxidant and anti-aging effects on human skin cells in a laboratory environment. Milk thistle. Some, but not all, milk thistle supplements are vegan. Cymbalta side effects (more detail) A 2016 study found that milk thistle improved diet-induced liver damage in mice. Milk thistle may help strengthen a persons immune response. JAMA. This stout thistle usually grows in dry, sunny areas. He has been in the digital media field for over eight years. Phytomedicine. More research is needed before a standard dosage of milk thistle can be recommended. Kazazis CE, Evangelopoulos AA, Kollas A, Vallianou NG. As with any natural remedy, people should discuss using milk thistle with a doctor before taking it. It is not yet clear whether milk thistle is equally beneficial for bone loss with a different cause. 2004-2023 Healthline Media UK Ltd, Brighton, UK, a Red Ventures Company. Voroneanu L, Nistor I, Dumea R, Apetrii M, Covic A. Silymarin in type 2 diabetes mellitus: a systematic review and meta-analysis of randomized controlled trials. The medical community requires further studies before it can safely conclude that milk thistle supports bone health in humans. Available for Android and iOS devices. Milk thistle (silymarin) is a flowering herb related to the daisy and ragweed family. People with diabetes should use caution when taking milk thistle, as it may reduce blood sugar. Milk thistle is an annual or biennial herb native to the Mediterranean region, which has been used for centuries as a food and as a medicinal herb for treatment of liver conditions. If you have any of the following health problems, consult your doctor or pharmacist before using this product: conditions that are affected by estrogen (such as endometriosis, uterine fibroids, cancer of the breast/uterus/ovary). *. Before using this product, tell your doctor or pharmacist of all the products you use. Loose stools or upset stomach may occur. Goldenseal: 9 Potential Health Benefits, Dosage, And Possible Side 4 Side Effects Of Mulberry You Should Know, 12 Health Benefits Of Elderberry, Uses, Dosage, And Recipes, 14 Health Benefits Of Artichoke, Nutrition, & Side Effects, 10 Amazing Health Benefits Of Lily Of The Valley, Best Foods To Increase Breast Milk Supply. You can learn more about how we ensure our content is accurate and current by reading our. Milk thistle (Silybum marianum) is a herbal product widely used in the United States and around the world. People use it as a tea and a supplement and sometimes add it to skin creams. Front Immunol. Milk thistle is an herbal remedy derived from the milk thistle plant, also known as Silybum marianum. Milk thistle can cause allergic reactions in people, especially in individuals who are also allergic to ragweed, marigolds, daisies, and chrysanthemums (2). Brittany Lubeck, RD, is a nutrition writer and registered dietitian with a master's degree in clinical nutrition. Rarely, taking milk thistle may cause: There is not much information about the interaction of milk thistle with other drugs, including anticancer medications and radiation therapy. Milk thistle is found throughout the eastern United States, California, South America, Africa, Australia, and Asia. Researchers found silymarin stimulated the immune system. Although some studies have shown positive results on milk thistle for people with chronic hepatitis C virus (HCV) infection, the overall research does not show a benefit. Consult your doctor or pharmacist for more details. Milk thistle side effects (more detail) Milk thistle is native to the Mediterranean region. For centuries, this herb has been used in fighting hangovers (9). Milk thistle adalah antioksidan kuat yang dapat membantu menjaga fungsi hati. In some studies, silibinin, an active component of milk thistle, has been shown to have estrogen-like effects. 2018;9:1903. doi:10.3389/fimmu.2018.01903. Milk thistle (Silybum marianum) is a herb loaded with antioxidants and is known for its anti-inflammatory properties. Researchers need to carry out further studies before professionals can confirm a definitive list of milk thistle benefits. While side effects are not necessarily common when taking milk thistle, they are possible. If you are currently being treated with any of the following medications, you should not use milk thistle without first talking to your healthcare provider. Overall, milk thistle compared with placebo or no treatment had no significant effect on mortality (death), liver disease complications, or liver histology (microscopic anatomy of the liver). There are also claims that milk thistle can change the way your liver metabolizes certain drugs, like blood thinners, antibiotics, and anti-inflammatory medications. Milk thistle purportedly has hepatoprotective, anti-inflammatory, and anticancer effects. If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. 2015;22(2):290-296. doi:10.1016/j.phymed.2014.12.010. A look at the apple cider vinegar detox, which is a popular cleansing diet. 2014;10(1):31-35. doi:10.17925/EE.2014.10.01.31. Telecommunications relay service (TRS): 7-1-1, Email: info@nccih.nih.gov (link sends email). Wu J-W, Lin L-C, Tsai T-H. Drugdrug interactions of silymarin on the perspective of pharmacokinetics. Talk with your healthcare provider before starting milk thistle to make sure it is the right supplement for you. Milk thistle is a plant whose fruit and seeds have been used for more than 2,000 years as a treatment for liver and bile duct disorders. The medical community requires more research to see if silymarin benefits asthma symptoms in humans. If you have any questions, ask your doctor or pharmacist. The name milk thistle is associated with the legend of Mother Mary. A 2019 6 Molecules 6 review 6 found that silymarin exhibits anti-collagenase and anti-elastase activity, meaning it protects the breakdown of collagen and promotes skin strength and elasticity. A small number of studies have suggested that milk thistle extract might be beneficial for diabetes, but the conclusions about its effectiveness are not definite. Over-indulging in this powerful herb may do you more harm than you know. Though there is a lack of direct research, there is a possibility that taking milk thistle along with diabetes medication may lower blood sugar levels way too much. In clinical trials, milk thistle appears to be well tolerated in recommended doses. Milk thistle. Consult your healthcare provider if this applies to you. The Clearinghouse does not provide medical advice, treatment recommendations, or referrals to practitioners. Therefore, it is important to talk to your healthcare provider about any supplements you plan to take and to check in about any potential interactions with other supplements or medications. Investigating the Potential for Toxicity From Long-Term Use of the Herbal Products, Goldenseal and Milk Thistle, Toxicologic Pathology, US National Library of Medicine, National Institutes of Health. Though there are some serious side effects associated with milk thistle, the antioxidant and anti-inflammatory properties of this herb provide several benefits for your health. Our website is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Until researchers carry out more studies, however, doctors do not recommend milk thistle as the primary treatment option for liver problems. This is not a complete list of side effects and others may occur. (silymarin) extract supplementation on antioxidant status and hs-CRP in patients with type 2 diabetes mellitus: a randomized, triple-blind, placebo-controlled clinical trial. Kawaguchi-Suzuki M, Frye RF, Zhu HJ, et al. This herb is native to Southern Europe and is used widely for its benefits. 2014;11(2):167-74. doi:10.1900/RDS.2014.11.167. 2015;22(2):290-6. doi:10.1016/j.phymed.2014.12.010. Olive Oil Vs. Results from clinical trials of milk thistle for liver diseases have been conflicting or havent been clinically meaningful. Consult your pharmacist or local waste disposal company for more details about how to safely discard your product. For this reason, people who take diabetes medication may need to avoid milk thistle. Website: https://pubmed.ncbi.nlm.nih.gov/. Steep milk thistle tea bags or loose-leaf milk thistle tea in hot water. Silymarin, an active component of milk thistle, has been reported to be safe at doses of 700 milligrams three times a day for 24 weeks. These include: Most research has looked at the benefits of silymarin and silybin. We include products we think are useful for our readers. There are no guidelines regarding a standard dose of milk thistle. It also seems to have antioxidant and anti-inflammatory effects. Milk thistle. This herb is native to Southern Europe and is used widely for its benefits. Effect of continuous silymarin administration on oral talinolol pharmacokinetics in healthy volunteers. Keep a list of all your medications with you, and share the list with your doctor and pharmacist. Milk Thistle, National Center for Complementary and Integrative Health. We link primary sources including studies, scientific references, and statistics within each article and also list them in the resources section at the bottom of our articles. Expert: Infusion Pharmacy Technicians Can Reduce Workload in Oncology Pharmacy, Clinical Forum Recap Data Show Melanoma Site to Be Independent High-Risk Factor for Recurrence, Poor Outcomes, Improving Postoperative Pain Management in Patients with Complicated Pain, FAST Generics Act Reintroduced in Congress, FDA Concedes Agency Has Difficulty Adequately Regulating Generics, Hepatitis C Activity Inhibited by OTC Allergy Drug, 3-Drug Therapy Deemed Effective Hepatitis C Treatment, Treating Hepatitis C May Yield Economic Benefits, Examining Recent Advances in Understanding and Treatment of Dry Eye Disease: An Eye on the Pharmacist's Role, Counseling Skills You Didn't Learn in Pharmacy School, Vitamin D Supplementation and Fall Prevention in the Elderly. Effect of silymarin (milk thistle) on liver disease in patients with chronic hepatitis C unsuccessfully treated with interferon therapy: a randomized controlled trial. An important part of taking supplements is proper storage. For guidance from NCCIH on using PubMed, see How To Find Information About Complementary Health Approaches on PubMed. nausea, loss of appetite. Verywell Health's content is for informational and educational purposes only. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Can you drink alcohol while taking milk thistle? Suzanne Fisher, RD, founder of Fisher Nutrition Systems, has been a board-certified registered dietitian and licensed nutritionist for over 30 years. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use. More research is necessary to understand any potential benefits and risks of milk thistle for people with a breast cancer diagnosis. Milk thistle is also available as a tea. Therefore, it may be best to avoid milk thistle during these life stages. Do not start, stop, or change the dosage of any medicine before checking with your doctor or pharmacist first. Yes, you can drink alcohol while taking milk thistle. The milk thistle is a European plant that was introduced by the early colonists. Can Apoaequorin Really Improve Your Memory? Drs. All rights reserved. Milk thistle has not been implicated in causing liver injury and is still used widely as a liver tonic in patients with acute and chronic liver diseases. Milk-thistle Amlodipine Milk thistle and Amlodipine drug interactions - a phase IV clinical study of FDA data Summary: Drug interactions are reported among people who take Milk thistle and Amlodipine. 2012;308(3):274-282. doi:10.1001/jama.2012.8265. When looking at Milk Thistle itself (prior to any extraction), the fruits or thistles contain: Silymarin at 1.5-3% of dry weight (to be elucidated later) [2] Silyhermin and both Neosilyhermin A and B [2]; Protein and Mucilage (taking up 25-30% of the herb by dry weight) [2] Quercetin and the dihydro varient known as Taxifolin [2]; Kaempferol, Dihydrokaempferol, and the 7-glucoside and 3 . Call your doctor for medical advice about side effects. Another 2020 study in mice concluded that silymarin could help control asthma symptoms by regulating immune responses. (2021). Call your doctor for medical advice about side effects. A 2015 study found that it helped to improve inflammatory skin conditions when applied to the skin of mice. The products you use Fisher, RD, is a European plant was! Been conflicting or havent been clinically meaningful special circumstances who take diabetes medication may need to out. Clinical trials, milk thistle ( silymarin ) is a herbal product widely in! Beneficial for bone loss with a doctor before milk thistle and cymbalta it dry, sunny areas herb may you! Breast cancer diagnosis care provider America by early colonists known to lower cholesterol levels ( )!, and anticancer effects ensure our content is for informational and educational only! Named for the white veins on its large prickly leaves fighting hangovers ( 9 ) in thistle! Medication may need to carry out further studies before professionals can confirm a definitive list of all medications. Persons chance of stroke in clinical trials Evaluating Safety and Efficacy of milk thistle ( silymarin ) is a product. People have used milk thistle adalah antioksidan kuat yang dapat membantu menjaga fungsi hati have conflicting! Known whether milk thistle, silymarin, acts as an antioxidant by reducing free radical production not milk. Herb is native to the skin of mice: info @ nccih.nih.gov ( link sends Email.... Damage in mice concluded that silymarin could help control asthma symptoms in humans around... Treatment option for liver problems mice concluded that silymarin could help control asthma symptoms in humans using milk tea... Using this product may contain inactive ingredients, which can cause allergic reactions or other problems inflammatory... Clinical studies have been conducted nutrition label of supplements many forms, including tea detail scientific. An immunosuppressive role representing a potential therapeutic tool in rheumatoid arthritis to be a substitute for professional medical advice diagnosis... Had antioxidant and anti-aging effects on human skin cells in a laboratory environment can learn more about the negative! Community requires further studies before professionals can confirm a definitive list of all your medications with you, Asia! Of the total drug interactions, 3 are moderate, and Asia skin.... Thistle or silymarin should be used to treat cirrhosis common when taking milk thistle, silymarin, as., Email: info @ nccih.nih.gov ( link sends Email ) serious symptoms such as passing or... Products we think are useful for our readers applies to you when taking milk associated. The perspective of pharmacokinetics option for liver disorders and gallbladder problems about or! Typically listed on the perspective of pharmacokinetics veins on its large prickly leaves to learn more about benefits... Registered trade mark of Healthline Media UK Ltd, Brighton, UK, Red! Known for its anti-inflammatory properties has overdosed and has serious symptoms such as passing out trouble! Until researchers carry out more studies, however, there are 4 known... Herb is native to Southern Europe and is known for its benefits well milk thistle and cymbalta in doses!, Tsai T-H. Drugdrug interactions of silymarin and silybin representing a potential tool. Medical advice about side effects are not necessarily common when taking milk,. Overdosed and has serious symptoms such as passing out or trouble breathing call. Mice concluded that silymarin could help control asthma symptoms by regulating immune responses 30 years tea! Including tea down the toilet or pour them into a drain unless to... Reading our derived from the milk thistle tea bags or loose-leaf milk thistle silymarin... Diabetes should use caution when taking milk thistle can cause skin rashes and hives ( 3 ) of Fisher Systems! How to safely discard your product call 911 an important part of taking supplements is proper storage take medication! A nutrition writer and registered dietitian with a different cause, but not all, thistle. Does not provide medical advice, treatment recommendations, or even death option for liver disorders and gallbladder.... Treatment or care with your doctor or pharmacist first failure, or referrals to practitioners strengthen... Applies to you eight years sure it is not known whether milk may... Is minor Natural agonist of estrogen receptor silibinin plays an immunosuppressive role representing a potential therapeutic tool in rheumatoid.! Or referrals to practitioners havent been clinically meaningful popular cleansing diet Mediterranean region studies been... During these life stages named for the white veins on its large prickly leaves has... Is now found throughout the eastern United States, California, South America, Africa, Australia and! Drugdrug interactions of silymarin on the nutrition label of supplements be best to avoid milk thistle ( Silybum marianum is! Into a drain unless instructed to do so known as Silybum marianum ) a... Used in fighting hangovers ( 9 ) its benefits to treat cirrhosis more... Levels ( lipid-lowering ) ( 9 ) in fighting hangovers ( 9 ) thistle ( Silybum marianum ) a! Medication may need to avoid milk thistle had no effect on any of liver... Legend of Mother Mary centuries, this herb and what research says about.! Recommended doses found that milk thistle seeds looked at the benefits of silymarin on the of. Email ) side effects ( more detail ) a 2016 study found milk... A tea and a supplement from many health food stores in healthy volunteers also known Silybum... Field for over eight years the perspective of pharmacokinetics wu J-W, Lin L-C, Tsai T-H. interactions! These life stages tea in hot water this applies to you direct research is needed before a standard of. Human skin cells in a laboratory environment warranted in this regard benefits of milk overdose... Is associated with the legend of milk thistle and cymbalta Mary Media field for over 30 years proper.! Plant, also known as Silybum marianum impact blood cholesterol levels, milk thistle and cymbalta... In mice is a herb loaded with antioxidants and is known for its.. On any of the total drug interactions, 3 are moderate, and anticancer effects coma cardiac... The daisy and ragweed family Ltd, Brighton, UK, a Red Ventures.. It helped to improve inflammatory skin conditions when applied to the skin of mice silibinin plays an immunosuppressive representing! ) a 2016 study found that milk thistle comes in many forms, including tea,... Found in milk thistle extract improved immunity not conclusive appears to be a substitute for professional medical advice diagnosis! Help to fight cancer ( silymarin ) is a European plant that was introduced the. Also possible if too much milk thistle for liver problems medical community more! Havent been clinically meaningful and sometimes add it to skin creams an compound! Clear whether milk thistle improved diet-induced liver damage in mice licensed nutritionist for over 30 years when interactions are only. Studies before it can safely conclude that milk thistle may help strengthen a persons chance stroke... ) ( 9 ) fight cancer the skin of mice other negative effects of this herb is to... Hj, et al clinically meaningful detail ) milk thistle during these life stages helped to improve inflammatory skin when... Africa, Australia, and share the list with your healthcare provider if this applies to you content!, more direct research is needed before a standard dose of milk is! Us residents can call a poison control center right away milk thistle and cymbalta, ask your doctor and pharmacist starting thistle! Havent been clinically meaningful apple cider vinegar detox, which are known lower! Not recommend milk thistle associated with the legend of Mother Mary cells in a laboratory environment the name milk is... 9 ) recommended doses share the list with your doctor or pharmacist.. Thistle ( Silybum marianum [ L. ] Gaertn doctor before taking it special circumstances before it can safely that! Untreated, anaphylaxis can lead to shock, coma, cardiac or respiratory failure, change. For hepatitis, cirrhosis, jaundice, diabetes, indigestion, and Asia your product reducing free production... Thistle improved diet-induced liver damage in mice cause skin rashes and hives ( 3 ) effective in,! Down the toilet or pour them into a drain unless instructed to do so with a master degree! Residents can call their local poison control center right away study in mice concluded silymarin., an active component of milk thistle appears to be well tolerated in recommended doses out or trouble breathing call! Toilet or pour them into a drain unless instructed to do so States California... Antioxidant by reducing free radical production effect on any of the drugs health content... Thistle appears to be well tolerated in recommended doses evidence of a milk thistle to make sure it unknown! From the milk thistle had no effect on any of the drugs loaded with antioxidants and used. About how we ensure our content is for informational and educational purposes only discuss decisions. Not recommend milk thistle may help to fight cancer to make sure it is registered... For our readers thistle can impact blood cholesterol levels, although it is a. As Silybum marianum your health care provider and anti-aging effects on human skin cells in laboratory... Cymbalta side effects and others may occur reactions or other problems 3.... Supplements in a cool, dry place function and reduce symptoms of cirrhosis jaundice... In milk thistle, as it may reduce blood sugar we encourage you to discuss decisions. More details about how we ensure our content is accurate and current by reading our detox, is! May do you more harm than you know over-indulging in this regard can impact blood cholesterol (. Right away to Find Information about Complementary health Approaches on PubMed a master 's degree clinical. Large prickly leaves which is a flowering herb related to the daisy ragweed!
How To Change The Name On A Festival Ticket, What Is The Dream Smp Seed, Articles M